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Channel blocker : ウィキペディア英語版 | Channel blocker A channel blocker (CB) or ion channel blocker (ICB) is a type of drug which binds inside the pore of a specific type of ion channel and blocks the flow of ions through it, resulting in an alteration of the electrochemical gradient of the cell membrane of neurons and therefore a change in neurotransmission. ==Types of Channel Blockers== There are several different major classes of channel blockers, including: * Calcium (Ca2+) channel blockers * Chloride (Cl−) channel blockers * Potassium (K+) channel blockers * Sodium (Na+) channel blockers The following types which act on ligand-gated ion channels (LGICs) via binding to their pore also exist: * 5-HT3 receptor antagonists * AMPA receptor antagonists * GABAA receptor antagonists * Glycine receptor antagonists * Kainate receptor antagonists * nACh receptor antagonists * NMDA receptor antagonists * P2X receptor antagonists * Zinc (Zn2+)-activated channel antagonists These types of receptor antagonists are referred to as noncompetitive or uncompetitive.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Channel blocker」の詳細全文を読む
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